Whats the best way to travel from panama to columbia?

I know theres a boat from the caribbean side of panama, but is it safe to bus from columbia to ecuador or am i gonna get my head blown off..
Answer
If you want a cruise, then do it, but is good r, quicker by plane. traveling from colombia to ecuador is not unsafe, but it would take you a couple of days, it is a long trip, so i would recommend you plane, but if you want to go by bus it is fine, but you have to prepare yourself...